The McKenna reaction – avoiding side reactions in phosphonate deprotection
نویسندگان
چکیده
منابع مشابه
Chiral preference of cutinase in the reaction with phosphonate inhibitors.
Introduction Lipases are lipolytic enzymes originating from a wide variety of sources, such as plants, microorganisms and higher animals. The most distinctive property of lipases is their rapid hydrolysis of ester bonds at an oil-water interface, whereas activity on monomeric substrates is generally low [l]. The first structures of lipases [2,3] already gave insight into their general architect...
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Deprotection of an N(α)-Fmoc-protected glycocysteine derivative 7 with an excess of morpholine unexpectedly led to the fluorenylmethyl-protected thioether 8 in high yield. The suggested mechanism for this reaction comprises the addition of the cysteine thiolate on the exocyclic double bond of dibenzofulvene, which is formed during Fmoc deprotection. The influence of base concentration on this t...
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When the range of the derivative of the nonlinearity contains the rst k eigenvalues of the linear part and a certain parameter is large, we establish the existence of 2k radial solutions to a semilinear boundary value problem. This proves the Lazer McKenna conjecture for radial solutions. Our results supplement those in 5], where the existence of k + 1 solutions was proven.
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2020
ISSN: 1860-5397
DOI: 10.3762/bjoc.16.119